Reynolds attributes Cable & Deadpool #2 to what got him hooked on the character and inspired him to bring the character to the movies. Reynolds himself would eventually portray the character in the X-Men film series, appearing in X-Men Origins: Wolverine (2009), Deadpool (2016), and its sequel Deadpool 2 (2018). In the 2004 series Cable & Deadpool, he refers to his own scarred appearance as Ryan Reynolds crossed with a Shar-Pei (though in the comic, Reynolds' name is misspelled as Renolds). The character's popularity has seen him featured in numerous forms of other media. The character is known as the Merc with a Mouth because of his tendency to talk and joke constantly, including breaking the fourth wall for humorous effect and running gags. A relatively unknown actor named Ryan Reynolds also makes an appearance as a high school football star named Jay Boom DeBoom.

Deadpool, whose real name is Wade Winston Wilson, is a disfigured mercenary with the superhuman ability of an accelerated healing factor and physical prowess. Initially Deadpool was depicted as a supervillain when he made his first appearance in The New Mutants and later in issues of X-Force, but later evolved into his more recognizable antiheroic persona. Created by writer Fabian Nicieza and artist/writer Rob Liefeld, the character first appeared in The New Mutants #98 (cover-dated February 1991).

Deadpool is a fictional character appearing in American comic books published by Marvel Comics.

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